BMJ Case Reports 2017; doi:10.1136/bcr-2016-218980

Taxan-associated nail toxicity

  1. Karl J Aichberger
  1. Krankenhaus der Barmherzigen Schwestern Linz, Linz, Austria
  1. Correspondence to Dr Bernhard Doleschal, bernhard.doleschal{at}
  • Accepted 20 January 2017
  • Published 31 January 2017


A woman aged 69 years treated with adjuvant docetaxel every 3 weeks for luminal-B breast cancer, presented with nail dystrophies.

On clinical examination, nested nail plates (figure 1A, C) divided by deep transverse sulci (figure 1B, D) on all 10 fingers were prominent. We counted three parallel grooves (figure 1B, D) with different distance to each other corresponding to three applied cycles of docetaxel. The second cycle of chemotherapy had to be postponed for 1 week due to febrile neutropenia reflected by a wider …

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