BMJ Case Reports 2017; doi:10.1136/bcr-2016-218730

Clear cell adenocarcinoma of cervix in 1-year-old girl without in utero exposure to diethylstilbestrol: an uncommon tumour at an uncommon age and site

  1. Nuzhat Husain1
  1. 1Department of Pathology, Dr Ram Manohar Lohia Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
  2. 2Fatima Hospital, Lucknow, Uttar Pradesh, India
  1. Correspondence to Dr Aditi Arora, draditiarora87{at}
  • Accepted 3 March 2017
  • Published 16 March 2017


Adenocarcinoma of cervix constitutes about 10–15% cases of carcinoma cervix. Clear cell variant is even a rarer variant of adenocarcinoma. It rarely occurs in the paediatric age group and a known risk factor is in utero exposure to diethylstilbestrol (DES). We report here a case of primary cervical tumour in a 1-year-old girl, which was initially suspected to be an embryonal rhabdomyosarcoma botryoides. Histopathology with immunohistochemical analysis revealed clear cell adenocarcinoma. There was no maternal history of DES intake during pregnancy. We discuss the histopathological characteristics and clinical course of this unusual tumour.


  • Contributors AA was involved in planning, conduct, reporting, conception and design, acquisition of data and analysis. AR contributed to conduct, reporting, conception and design, and interpretation of data. AN was involved in review of literature and manuscript writing. NH was involved in supervision, review of literature and analysis of data.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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