You are here

Article Text

Article menu
Download PDFPDF
CASE REPORT
Successful treatment of tumour-induced osteomalacia after resection of an oral peripheral ossifying fibroma
  1. Mark Anthony Santiago Sandoval1,2,
  2. Majorie Amoroto Palermo2,
  3. Ryner Carrillo3,
  4. Rafael Bundoc4,
  5. Jose Ma Carnate Jr5,
  6. Romelito Jose Galsim6
  1. 1Department of Physiology, College of Medicine, University of the Philippines Manila, Manila, Philippines
  2. 2Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  3. 3Department of Otorhinolaryngology, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  4. 4Spine Service, Department of Orthopedics, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  5. 5Departments of Pathology and Laboratories, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  6. 6Department of Radiology, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines
  1. Correspondence to Dr Mark Anthony Santiago Sandoval, markanthony_sandoval{at}yahoo.com

Summary

Tumour-induced osteomalacia is a paraneoplastic syndrome wherein bone is affected by a hormone from a tumour that causes renal phosphate wasting and hypophosphataemia. Here, we present the case of a 31-year-old man who has been suffering from generalised bone pains and a spine deformity that led to loss of height. Pertinent findings are low serum phosphorus, low vitamin D and decreased bone mineral density. These findings led to a diagnosis of osteomalacia. However, the finding of an oral mass raised some questions as to what role it plays in the patient's disease. It was suspected that the oral mass (fibroma) was producing a hormone that led to renal phosphate wasting, hypophosphataemia and then osteomalacia. This hypothesis was proven after surgical removal of the mass led to normalisation of the metabolic derangements and eventually led to a resolution of the bone pains.

https://doi.org/10.1136/bcr-2016-218637

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Twitter Follow Majorie Palermo @Majorie Palermo

    • Contributors MASS wrote the draft manuscript and was the attending physician of the patient. MASS, MAP, RC and RB took care of the patient with regard to the medical, endocrine, ENT and orthopaedic concerns. JMC was the pathologist who interpreted the histological specimens. RJG was the radiologist who interpreted the patient's X-ray images. All authors approved the final version of the manuscript.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.