BMJ Case Reports 2017; doi:10.1136/bcr-2016-218623
  • Reminder of important clinical lesson

Orlistat-induced oxalate nephropathy: an under-recognised cause of chronic kidney disease

  1. Beena Nair2
  1. 1Department of Renal Medicine, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK
  2. 2Department of Histopathology, Lancashire Teaching Hospitals NHS Foundation Trust, Preston, UK
  1. Correspondence to Dr Laurence Richard Solomon, laurie.solomon{at}
  • Accepted 30 October 2017
  • Published 12 November 2017


Two patients developed kidney failure due to oxalate deposition in the kidney while taking orlistat. Cessation of orlistat was followed by partial recovery of kidney function. The mechanism by which orlistat causes hyperoxaluria and the management of orlistat-induced oxalate nephropathy is reviewed. We suggest that all patients taking orlistat are at risk of this condition, which may develop insidiously and is easily overlooked. Monitoring of kidney function of patients taking orlistat is warranted.


  • Contributors LRS looked after the patients, made the diagnosis and wrote much of the report. BN reported the histopathology. LO contributed to patient care and wrote parts of the report. ACN wrote parts of the paper.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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