BMJ Case Reports 2017; doi:10.1136/bcr-2016-218617

Glioblastoma with primitive neuronal pattern in a girl aged 3 months: a rare diagnosis at an unusual age

  1. Chris Xenos1
  1. 1Department of Neurosurgery, Monash Health, Clayton, Victoria, Australia
  2. 2Department of Anatomical Pathology, Monash Health, Clayton, Victoria, Australia
  1. Correspondence to Dr Chi Hau Tan, chihautan{at}
  • Accepted 1 February 2017
  • Published 15 February 2017


A girl aged 3 months presented with multiple seizures within 12 hours and was noted to have a palpable swelling over the right temporal region. MRI of the brain revealed a large right frontotemporal tumour, suggestive of supratentorial primitive neuroectodermal tumour. She underwent a stealth-guided craniotomy and debulking of the tumour. Histopathology and immunochemistry of the specimen, however, indicated a high-grade tumour with glioblastoma and neuroblastic components. She underwent adjuvant chemotherapy following the surgery and is well at 7-month follow-up. This case underscores the importance of considering the rare entity of glioblastoma with primitive neuronal pattern as a differential diagnosis in a young child.


  • Contributors CHT was responsible for the literature review and writing of the article. CX performed the surgery. TBP and CX were responsible for correction of the article and supervision.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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