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CASE REPORT
Lymphomatoid granulomatosis with pulmonary and gastrointestinal involvement
  1. J H Kappen1,
  2. H C T van Zaanen2,
  3. S M Snelder3,
  4. A J P van Tilburg4,
  5. A Rudolphus1
  1. 1Department of Pulmonology, Sint Franciscus Vlietland Groep, Rotterdam, The Netherlands
  2. 2Department of Haematology, Sint Franciscus Vlietland Groep, Rotterdam, The Netherlands
  3. 3Department of Internal Medicine, Sint Franciscus Vlietland Groep, Rotterdam, The Netherlands
  4. 4Department of Gastroenterology and Hepatology, Sint Franciscus Vlietland Groep, Rotterdam, The Netherlands
  1. Correspondence to J H Kappen, j.kappen{at}franciscus.nl

Summary

We present a rare case of grade II lymphomatoid granulomatosis (LYG) with pulmonary and gastrointestinal involvement. LYG is considered an Epstein-Barr virus-driven lymphoproliferative disorder that often presents with multiple nodular lesions in the lungs and sometimes involvement of skin and the central nervous system. Although the aetiology is unknown, it is associated with the use of immunosuppressives. Involvement of other organ systems is very rare. We successfully treated our patients with 6 cycles of R-CHOP and autologous stem cell transplantation with a major response at 20 months follow-up.

https://doi.org/10.1136/bcr-2016-218369

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    Footnotes

    • Contributors JHK is responsible for writing the paper and literature study. HCTvZ is responsible for treatment patient, review paper and literature study. AJPvT is responsible for treatment patient and review paper. AR is responsible for treatment patient, review paper and guidance of process.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.