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  • Late spontaneous decapsulation of the kidney graft in a patient with hepatitis C and treated with sirolimus: possible pathophysiological association in a rare complication

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CASE REPORT
Late spontaneous decapsulation of the kidney graft in a patient with hepatitis C and treated with sirolimus: possible pathophysiological association in a rare complication
  1. Rita Leal1,
  2. Helena Pinto2,
  3. Rui Alves1,3,
  4. Arnaldo Figueiredo3,4
  1. 1Department of Nephrology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  2. 2Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  3. 3Universidade de Coimbra Faculdade de Medicina, Coimbra, Portugal
  4. 4Department of Urology and Kidney Transplantation, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal
  1. Correspondence to Dr Rita Leal, rita.gcleal{at}gmail.com

Summary

Late decapsulation with fluid collection is a rare complication of renal transplantation with deleterious effects on kidney function. Its physiopathology is unclear but there might be an association with mammalian target of rapamycin (m-TOR) inhibitors, especially in patients with chronic hepatitis C. We report a case of late spontaneous decapsulation 12 years after kidney transplant in a patient infected with hepatitis C under treatment with sirolimus. He underwent marsupialisation of the collection, sirolimus was converted to cyclosporine and hepatitis C treatment was performed with success. This is the first successful case report of late spontaneous decapsulation of the kidney graft in a patient with hepatitis C.

https://doi.org/10.1136/bcr-2016-218335

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    Footnotes

    • Contributors RL was involved in conception and design of the case report, acquisition of data, assembling relevant literature, write the article; HP was involved in data collection, assembling relevant literature; RA and AF were involved in conception, assembling relevant literature, critical review, supervise writing of the paper.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.