BMJ Case Reports 2017; doi:10.1136/bcr-2016-217687
  • Rare disease

Metaplastic breast carcinoma with chondroid differentiation: a rare variant of infiltrative carcinoma in a 38-year-old woman

  1. Mostafa Javannejad3
  1. 1Department of Pathology, Shahid Sadoughi University of Medical Sciences, Mortaz General Hospital, Yazd, Iran
  2. 2Department of Pathology, Mortaz General Hospital, Yazd, Iran
  3. 3Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  1. Correspondence to Professor Shokouh Taghipour Zahir, taghipourzahirsh{at}
  • Accepted 29 May 2017
  • Published 15 June 2017


Metaplastic breast carcinoma (MBC) is a rare type of invasive breast carcinoma, and chondroid differentiation is even rarer. Here we report a case of MBC with extensive chondroid differentiation in a 38-year-old woman who presented with a lump in her left breast. Ultrasound findings were most compatible with those of giant fibroadenoma. A histopathological examination revealed a malignant lesion comprising neoplastic epithelial cells arranged in solid nests, with large areas of chondroid differentiation. Neoplastic chondroid cells exhibited a positive reaction for S-100, patchy positive reaction for pan-cytokeratin (AE1/AE3) and negative reaction for epithelial membrane antigen. Both carcinomatous and chondroid cells exhibited p53 overexpression. Sentinel lymph node biopsy revealed no tumorous involvement.


  • Contributors Both authors had contributed in case presentation, clinical investigation and writing the manuscript.

  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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