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Novel PPP1CB-ALK fusion protein in a high-grade glioma of infancy
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  1. Yasmin Aghajan1,
  2. Michael L Levy2,
  3. Denise M Malicki3,
  4. John Ross Crawford4
  1. 1University of California, San Diego, School of Medicine, La Jolla, California, USA
  2. 2Department of Neurosurgery, University of California San Diego, San Diego, California, USA
  3. 3Department of Pathology, Rady Children's Hospital University of California San Diego, San Diego, California, USA
  4. 4Department of Neurosciences and Pediatrics, University of California San Diego, San Diego, California, USA
  1. Correspondence to Dr John Ross Crawford, jrcrawford{at}ucsd.edu

https://doi.org/10.1136/bcr-2016-217189

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    Description

    A 3-month-old previously healthy girl presented to the hospital with sudden onset altered mental status and cardiopulmonary arrest. Her right pupil was fixed and dilated. Emergent CT scan showed a massive 10.2 cm hyperdense lesion occupying the right cerebral hemisphere with areas of acute haemorrhage causing subfalcine, uncal and inferior cerebellar herniation with obstructive hydrocephalus and diffuse cerebral oedema (figure 1). Emergent craniotomy was performed for evacuation of the haematoma and gross total resection of the mass in the absence of preoperative MRI. Neuropathology revealed a malignant glial tumour with prominent endothelial proliferation (figure 2). Molecular analysis of the tumour demonstrated a novel PPP1CB-ALK fusion protein. Given the patient's young age and gross total resection, the decision was made not to proceed with chemotherapy. The child remains disease-free at 3 years postdiagnosis with significant motor and neurocognitive delays.

    Figure 1
    Figure 1

    Axial CT image at presentation showing large hyperdense lesion in right cerebral hemisphere with areas of acute haemorrhage, vasogenic oedema and midline shift.

    Figure 2
    Figure 2

    Neuropathology reveals a hypercellular glial tumour with pleomorphic nuclei and endothelial proliferation consistent with a high-grade glioma (×400).

    Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase first discovered in anaplastic large cell lymphomas.1 ALK fusion proteins are oncogenic, as they activate intracellular signalling cascades such as the Ras-ERK, JAK3-STAT3 and PI3K-Akt pathways,1 and PPP1CB, a serine/threonine phosphatase, has been implicated in activating those pathways.2 The EML4-ALK translocation is the more prevalent ALK mutation in solid cancers, present in 6% of non-small cell lung cancers.1 However, ALK fusion proteins have not classically been implicated in primary CNS solid tumours, making this high-grade glioma of infancy a rare and unique case. In conclusion, our findings revealed the first PPP1CB-ALK fusion protein mutation in a primary CNS tumour.

    Learning points

    • Anaplastic lymphoma kinase (ALK) fusion proteins are classically implicated in anaplastic large cell lymphoma and non-small cell lung cancer but not in primary CNS solid tumours.

    • This case of high-grade glioma of infancy revealed a novel PPP1CB-ALK fusion protein successfully treated with surgery alone.

    • Further studies are necessary to understand the role of ALK fusion proteins in the pathogenesis and treatment of CNS neoplasms.

    References

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    View Abstract

    Footnotes

    • Twitter Follow Yasmin Aghajan at @yaghajan

    • Contributors YA, JRC, MLL and DMM were all involved in analysis and interpretation of this case. All authors have made substantial contributions and were involved in drafting and revising this work. All authors have reviewed the case report and agree to its content prior to submission.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.