BMJ Case Reports 2016; doi:10.1136/bcr-2016-216890

Aspirin unmasking acquired haemophilia A in a patient with prostate cancer

  1. Faiza Murad4
  1. 1Department of Medicine, Sligo University Hospital, Sligo, Ireland
  2. 2Sligo University Hospital, Sligo, Ireland
  3. 3Galway University Hospitals, Galway, Galway, Ireland
  4. 4Mercy University Hospital, Cork, Ireland
  1. Correspondence to Dr Julie Omolola Okiro, Julieokiro{at}
  • Accepted 17 August 2016
  • Published 8 September 2016


A 72-year-old man, on treatment for prostate cancer, attended the emergency department with his 2nd episode of spontaneous extensive bruising and haematomas. His first presentation was 2 months prior but this was thought to be because of his aspirin and he improved when aspirin was discontinued. On this occasion aspirin had been restarted 7 days before he developed his symptoms. His blood investigation was significant for a much raised activated partial thromboplastin time (aPTT). On his 3rd day of admission he deteriorated clinically with a drastic drop in his haemoglobin and worsening tense haematomas. Blood investigations confirmed the diagnosis of acquired factor VIII deficiency and he subsequently received treatment with factor VIII inhibitor bypassing activity, steroids and immunosuppresants.

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