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Description
A 58-year-old woman with a history of poorly controlled type 2 diabetes, hypertension and smoking presented with a left hemiparesis (grade 4/5). Admission glucose was 22.6 mmol/L. MRI of the brain demonstrated an area of restricted diffusion involving the corpus callosum of the left hemisphere (figures 1 and 2). Investigations into the cause of her stroke including vasculitic and thrombophilic causes, echocardiogram, telemetry and carotid Doppler, did not demonstrate any significant pathology. Rather alarmingly, the patient's glycated hemoglobin was elevated at 134 mmol/mol.
During her rehabilitation, further difficulties were identified. Cognitive impairment was identified (Montreal Cognitive Assessment (MOCA) score 10/30), with deficits affecting all categories. As the power in the patient's left arm improved, she described unintended purposeful autonomous movements of her left arm and intermanual conflict, whereby her left hand would undo whatever act her right hand had voluntarily completed, for example, when opening a cupboard door with her right hand, her left hand would close it again. This phenomenon has also been termed the ‘anarchic hand syndrome’. These experiences were intermittent and occasional, and therefore did not detract from the patient's rehabilitation.
At follow-up 2 months later, her cognition was continuing to improve (MOCA score 21/30), though the involuntary movements continued.
Infarctions of the corpus callosal are rare due to its vascular supply originating from the anterior cerebral and posterior cerebral arteries. In one case series, the corpus callosum was affected in 3.6% of all patients with stroke.1 Causes are vascular in almost half the cases, and include the usual risk factors as well as vasculitis and hypercoagulable states; non-vascular causes including trauma, tumour and demyelination account for the remainder.2
In this patient, the traditional risk factors described above were aggressively managed and antiplatelet medication was prescribed.
Learning points
Corpus callosal infarctions are rare and their symptoms wide-ranging. These include hemiparesis, dysphasia and altered consciousness as well as anarchic/alien hand syndrome.
A ‘stroke’ affecting the corpus callosum should prompt a thorough assessment for alternative causes, for example, inflammatory, vasculitis, malignancy, etc, as traditional risk factors account for 35% of all cases.2 Further investigations in this patient were not indicated since her risk factors, clinical course and investigation findings suggested an atherosclerotic pathophysiology.
Footnotes
Competing interests None declared.
Patient consent Obtained.
Provenance and peer review Not commissioned; externally peer reviewed.