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CASE REPORT
Prenatal constriction of the ductus arteriosus following maternal diclofenac medication in the third trimester
  1. Karoline Aker1,
  2. Anne Brantberg2,3,
  3. Siri Ann Nyrnes1,4
  1. 1Department of Pediatrics, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
  2. 2Department of Gynecology and Obstetrics, National Center for Fetal Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
  3. 3Department of Laboratory Medicine, Children's and Women's Health, Norwegian University of Science and Technology, Trondheim, Norway
  4. 4Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
  1. Correspondence to Karoline Aker, karoline.aker{at}ntnu.no

Summary

We describe a case of a 21-year-old primigravida at 36 weeks’ gestation who was admitted to a local hospital because of abdominal pain. She was prescribed a total of six doses of diclofenac 50 mg over 2 days. One day later, there was difficulty registering the fetal heartbeats on cardiotocography. Ultrasound examination revealed a fetus with ascites and pathological flow over the tricuspid valve. The patient was referred to a tertiary centre for fetal medicine. Fetal echocardiography revealed, in addition to ascites and tricuspid regurgitation, a constricted ductus arteriosus, dilated right ventricle and reduced flow in the pulmonary artery. Immediate caesarean section resulted in an excellent neonatal outcome.

https://doi.org/10.1136/bcr-2015-210473

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