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Description
A 60-year-old woman with type 1 diabetes mellitus and a history of repeated urinary tract infections due to Proteus mirabillis presented with diffuse palmoplantar hyperkeratosis of 4 months duration (figure 1) and acute retrosternal pain. An ECG showed a diffuse concave ST segmental elevation and the echocardiogram showed a mild pericardial effusion, suggestive of pericarditis. Laboratory analysis showed negative troponin, leucocytosis, elevated erythrocyte sedimentation rate (110 mm/h) and C reactive protein (10 mg/dL). A CT scan revealed a hydronephrotic, non-functioning left kidney with an inflammatory infiltrate in the perinephric fat and a bilateral coraliform calculus. A left radical nephrectomy was performed and the histological diagnosis of xantogranulomatous pyelonephritis was confirmed (figure 2A, B). Complete clinical remission of the cutaneous lesions and pericarditis was observed 1 month after surgery.
Palmoplantar keratoderma is characterised by abnormal thickening of the skin on the palms and soles. It can be hereditary or acquired; when acquired it is associated with malignancy, drugs, infections and chronic systemic diseases, but it can also be idiopathic.1
Xanthogranulomatous pyelonephritis is an uncommon chronic destructive inflammatory disease of the renal parenchyma. Most cases occur in the setting of obstruction due to infected renal stones, mostly by Escherichia coli and P. mirabillis.2
To the best of our knowledge, this is the first case reported of acquired palmoplantar keratoderma associated with xanthogranulomatous pyelonephritis.
Learning points
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Acquired palmoplantar keratoderma is a multiaetiological disorder and may be the first manifestation of a systemic disease.
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Recognition of the underlying cause is essential for successful treatment.
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Although very rare, xanthogranulomatous pyelonephritis should be considered in the differential diagnosis of palmoplantar keratoderma.
Acknowledgments
The authors thank Dr Sílvia Coelho for her contribution to this article.
Footnotes
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Contributors JC and MFN participated in drafting of the manuscript. JDA and SO revised it critically for important intellectual content. All the authors contributed to conception of the work and acquisition of data. All authors approved the final version to be published.
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Competing interests None.
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Patient consent Obtained.
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Provenance and peer review Not commissioned; externally peer reviewed.