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CASE REPORT
Takayasu's arteritis occurring under TNF-α blockers: a new paradoxical effect?
  1. Leila Souabni,
  2. Kaouther Ben Abdelghani,
  3. Saoussen Jradi,
  4. Leith Zakraoui
  1. Department of Rheumatology, Mongi Slim Hospital, La Marsa, Tunisia
  1. Correspondence to Dr Kaouther Ben Abdelghani, kawther_ba{at}yahoo.fr

Summary

Takayasu’s arteritis (TA) is a rare granulomatous vasculitic disease. Recently, experimental studies and several case reports have supported the use of anti-tumour necrosis factor (TNF) therapy for severe forms of TA. We report a case of a 58-year-old woman who was followed for spondyloarthritis. Her disease was resistant to non-steroidal anti-inflammatory drugs, and TNF-α blockers were initiated. The patient developed asthaenia and severe back pain. The erythrocyte sedimentation rate was 82 mm and C reactive protein was 192 mg/L. Based on thickened walls of large vessel on MRI, a diagnosis of TA was established. Under corticosteroids and after discontinuation of TNF-α blockers, the patient remained free of symptoms at 8-month follow-up.

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