BMJ Case Reports 2014; doi:10.1136/bcr-2013-203510

Extensive warfarin-induced skin necrosis successfully treated with negative pressure wound therapy

  1. Patsy Lenane1
  1. 1Dermatology Department, Mater Misericordiae University Hospital, Dublin, Ireland
  2. 2Geriatric Medicine, Dublin, Ireland
  3. 3Department of Histopathology, Mater Misericordiae University Hospital, Dublin, Ireland
  1. Correspondence to Dr Aizuri A Murad, aiz100{at}
  • Accepted 25 March 2014
  • Published 17 April 2014


A 55-year-old woman presented with an extensive warfarin-induced skin necrosis while an inpatient for treatment of a pulmonary embolism and thromboembolic stroke. She had a background of diabetes mellitus, hypertension and dyslipidaemia. Her warfarin was stopped and she was anticoagulated with low-molecular weight heparin. The wound was successfully treated with a combination of antibiotic, debridement and negative pressure wound therapy.

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