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Pneumoperitoneum and pneumatosis cystoides intestinalis (PCI) following chemotherapy in an adolescent with Hodgkin's lymphoma
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  1. Ramnik V Patel1,2,
  2. Paul Anthony Sutton3,
  3. Daniel Colliver4,
  4. Richard Stewart4
  1. 1Department of Paediatric Urology, University College London Hospitals NHS Foundation Trust, London, UK
  2. 2Department of Paediatric Urology, Great Ormond Street Children Hospital NHS Trust, London, UK
  3. 3Department of Molecular and Clinical Cancer Medicine, University of Liverpool, Liverpool, UK
  4. 4Department of Paediatric Surgery, QMC, Nottingham, UK
  1. Correspondence to Ramnik V Patel, ramnik{at}doctors.org.uk

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Description

A 14-year-old boy presented to the children's emergency department with cough, fever and dizziness which failed to respond to antibiotics. Examination revealed a 6 cm × 4 cm firm lymph node in the anterior right cervical chain and a chest X-ray showed a mediastinal mass. A CT scan demonstrated enlarged bilateral neck nodes, an 11 cm mediastinal mass with tracheal compression, an abdominal mass extending from the tail of the pancreas, enlarged coeliac lymph nodes, splenic and bilateral renal deposits consistent with Hodgkin's lymphoma, which was subsequently confirmed by open biopsy and histology of the cervical lymph node. Following the insertion of a Broviac line, he was started on a regimen of chemotherapy (COPADM 1). Prior to discharge some difficulty with aspirating the line was noted by the ward staff and a chest X-ray confirmed that the line was correctly placed and demonstrated an incidental finding of free air under the diaphragm (figure 1). While on conservative management, he developed abdominal pain referred to shoulder tip with abdominal distention and tenderness. At laparoscopy, pneumatosis intestinal was found in the ascending and transverse colon and an ileostomy was fashioned. He recovered with bowel function returning completely within 72 h. Chemotherapy was recommenced 11 days later. Ileostomy was closed in 8 weeks. On follow-up, he remained asymptomatic, is thriving well with normal gastrointestinal function. Pneumoperitoneum and pneumatosis cystoides intestinalis can develop after chemotherapy which are relatively rare and in most instances may have a benign self-limiting course but they may become symptomatic and require further intervention as demonstrated by our case.1–3

Figure 1

(A) Preoperative chest radiographs showing pneumoperitoneum and (B) Postoperative one demonstrating normal appearance.

Learning points

  • Chemotherapy-induced pneumatosis cystoides intestinalis (PCI; gas-filled cysts of the submucosa or subserosa of the bowel that can lead to pneumoperitoneum) is a relatively rare and mostly self-limiting condition. However, pneumoperitoneum in a child with lymphoma treated with chemotherapy is an ominous sign suggestive of gastrointestinal perforation.

  • Conservative management in such cases includes oxygen, metronidazole and parenteral nutrition initially but if they become symptomatic and ill may require further laparoscopic or open intervention.

  • Chest radiograph in upright position may reveal pneumoperitoneum, laparoscopy shows extensive PCI on colon and laparoscopic or open temporary diversion resolves the symptoms effectively.

References

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Footnotes

  • Contributors All the authors have made substantial contributions to the conception and design of this paper, search of literature, the acquisition, analysis and interpretation of the data, to drafting the article or revising it critically for important intellectual content, and to the final approval of the version to be published.

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.