rss
BMJ Case Reports 2014; doi:10.1136/bcr-2013-201982
  • CASE REPORT

A rare presentation of an ancient disease: scurvy presenting as orthostatic hypotension

  1. David Juurlink2
  1. 1Department of Internal Medicine, University of Toronto, Toronto, Canada
  2. 2General Internal Medicine and Clinical Pharmacology, University of Toronto, Toronto, Canada
  1. Correspondence to Dr Jonathan Samuel Zipursky, jonathan.zipursky{at}gmail.com
  • Accepted 6 May 2014
  • Published 23 May 2014

Summary

A 49-year-old man presented to hospital with severe orthostatic hypotension, gingival dysplasia and a purpuric rash involving his extremities. The orthostatic hypotension failed to respond to fluids and, on the basis of physical examination and dietary history, the patient was given a preliminary diagnosis of scurvy (ascorbic acid deficiency). Serum ascorbic acid levels were undetectable and the orthostasis was resolved within 24 h of ascorbic acid replacement. The pathogenesis of orthostatic hypotension in the setting of scurvy appears to involve impaired catecholamine synthesis and attenuated vasomotor response to α-adrenergic stimulation. We believe that this case describes a rare presentation of scurvy and highlights a previously under-reported connection between scurvy and vasomotor instability.

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article