Summary

Autosomal dominant polycystic kidney disease (ADPKD) is well known for its different renal and extrarenal complications. Chronic renal failure (CRF) from ADPKD is also reported in older patients. On the other hand, multiple myeloma (MM) can also cause renal damage by different mechanisms. A 38-year-old man presented with dull aching abdominal pain, recent onset respiratory distress along with bilateral pedal swelling. Initial investigations revealed polycystic kidney disease but subsequently it was found that the patient was also suffering from MM. This rare association of ADPKD and MM was responsible for aggravating the renal damage and perhaps resulted in early age of presentation with CRF. The patient was managed symptomatically but unfortunately succumbed before starting specific treatment for MM.