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CASE REPORT
Long-term fundus changes in acquired partial lipodystrophy
  1. Joyce Jansen1,
  2. Lien Delaere2,
  3. Leigh Spielberg3,
  4. Anita Leys2
  1. 1University Hospitals Leuven, Leuven, Belgium
  2. 2Department of Ophthalmology, University Hospitals Leuven, Leuven, Belgium
  3. 3Oogziekenhuis, Rotterdam, The Netherlands
  1. Correspondence to Dr Joyce Jansen, joyce.jansen{at}uzleuven.be

Summary

We describe long-term fundus changes in a patient with partial lipodystrophy (PL). Retinal pigment alterations, drusen and subretinal neovascularisation were seen without evidence for membranoproliferative glomerulonephritis. Fundus alterations similar to those seen in age-related macular degeneration can occur at an earlier age in patients with PL, even without renal disease. Dysregulation of an alternative complement pathway with low serum levels of C3 has been implicated as a pathogenetic mechanism.

https://doi.org/10.1136/bcr-2013-201218

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