BMJ Case Reports 2013; doi:10.1136/bcr-2013-009532

Tumour lysis syndrome in a patient with intravascular spread from a recurrent epithelial ovarian cancer

  1. Sarah Blagden3
  1. 1Imperial College Healthcare NHS Trust, London, UK
  2. 2Intensive Care Unit, Imperial College Healthcare NHS Trust, Charing Cross Hospital, London, UK
  3. 3Department of Oncology, Imperial College Healthcare NHS Trust, Hammersmith Hospital Campus, London, UK
  1. Correspondence to Sarah Blagden, s.blagden{at}


Tumour lysis syndrome is a potentially life-threatening oncological emergency most commonly encountered in patients with rapidly proliferating, treatment-responsive haematological malignancies. It is rarely observed in solid tumours and, to our knowledge, this is the first time that it has been reported in a cancer with an intravascular tumour extension. In this report, we describe a case of a woman who presented with recurrent ovarian cancer and was found to have tumour invading into her vasculature. The patient subsequently developed tumour lysis syndrome after receiving chemotherapy. The case highlights the importance of considering tumour lysis syndrome prophylaxis when treating patients with intravascular involvement from a solid malignancy even if, as in this case, it is a recurrent tumour. Included is a brief review of the literature. We propose that ‘intravascular tumour invasion is recognised as an important risk factor for the development of tumour lysis syndrome.

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