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BMJ Case Reports 2013; doi:10.1136/bcr-2013-009329
  • CASE REPORT

Retroperitoneal amyloidosis as the presenting manifestation of Waldenstrom's macroglobulinaemia

  1. Jay Yang3
  1. 1Department of Internal Medicine, Wayne State University, Detroit, Michigan, USA
  2. 2Department of Internal Medicine, Huron Valley Sinai Hospital, Commerce Township, Michigan, USA
  3. 3Deparment of Oncology, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA
  1. Correspondence to Dr Domingo Franco-Palacios, dfrancopalacios{at}gmail.com

Summary

Retroperitoneal amyloidosis has been described in a few case reports and is typically a secondary manifestation of inflammation or malignancy. We present the case of a 69-year-old man who presented with a large pleural effusion and an incidental retroperitoneal mass in the CT imaging. Further investigation confirmed the diagnosis of amyloid amyloidosis involving the retroperitoneum as well as a concurrent Waldenstrom's macroglobulinaemia. Chemotherapy consistent of drugs active against both the lymphoid and plasma cell components of the disease is the proposed therapy for Waldenstrom's macroglobulinaemia in those patients amenable to receive chemotherapy and can make a difference in the survival.

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