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BMJ Case Reports 2013; doi:10.1136/bcr-2013-008743
  • CASE REPORT

Haemophagocytic syndrome with disseminated intravascular coagulation associated with tuberculosis

  1. Narjess Khalfallah
  1. Department of Internal Medicine, Charles Nicolle's Hospital, Tunis, Tunisia
  1. Correspondence to Dr Eya Cherif, eyacherif{at}yahoo.fr

Summary

Haemophagocytic syndrome (HPS) is a clinical entity that combines non-specific clinical and biological features. The diagnosis is usually confirmed by a bone marrow examination. HPS may be primary or secondary to a malignancy or to an infectious or autoimmune disease. Early aggressive survey of the aetiology and optimal treatment of the underlying disease improve the outcome of life-threatening HPS. Infection-associated HPS occurs predominantly in immunocompromised patients and is usually fatal. Leading trigger agents are viruses, especially the Epstein-Barr virus  and cytomegalovirus. Mycobacterial infections associated with HPS are rare but should be considered in those patients where there is associated fever of unknown origin. We present a case of disseminated tuberculosis-associated HPS.

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