BMJ Case Reports 2013; doi:10.1136/bcr-2012-008273
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Hypothalamic hamartoma

  1. Paul Brennan
  1. Department of Neuroradiology, Beaumont Hospital, Dublin, Ireland
  1. Correspondence to Dr Reuben Grech, reubengrech{at}


A 9-year-old girl presented with an 8-month history of gelastic seizures and precocious puberty. Clinical evaluation including full neurological assessment was otherwise unremarkable. Endocrine tests were normal and there was no family or surgical history of note.

Hypothalamic or tuber cinereum hamartoma is a rare non-neoplastic heterotrophic lesion, which forms part of the spectrum of grey matter heterotopias. It is composed of a disorganised mass of neuronal cells within the tuber cinereum of the hypothalamus. It may occur either …

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