rss
BMJ Case Reports 2013; doi:10.1136/bcr-2012-007947
  • CASE REPORT

Purpura fulminans in a patient with mixed connective tissue disease

  1. Maureen Connolly1
  1. 1Dermatology Department, Adelaide and Meath Hospital, Dublin, Ireland
  2. 2Department of Pathology, Adeliade and Meath Hospital, Dublin, Ireland
  1. Correspondence to Dr Aizuri A Murad, aiz100{at}hotmail.com

Summary

A 43-year-old lady was admitted to the intensive care unit with sepsis. She had a history of mixed connective tissue disease, Raynaud's syndrome and hypothyroidism. 2 days later, she developed a purpuric rash on her face and extremities with a livedoid background. Few days later, her distal fingers and toes became gangrenous which then had to be amputated. Laboratory investigations showed that she was coagulopathic and had multiple organ dysfunctions. Antiphospholipid antibodies were negative; however, protein C and antithrombin III levels were low. A skin biopsy showed fibrinoid necrosis in the vessel wall with microthrombi and red-cell extravasation. A diagnosis of purpura fulminans was made.

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article