BMJ Case Reports 2013; doi:10.1136/bcr-2012-006672
  • Rare disease

Severe CMV complication following maintenance therapy with rituximab

  1. Adrian Tempescul2
  1. 1Department of Clinical Haematology, Institute of Cancerology and Hematology, University Hospital Brest, Brest, France
  2. 2Department of Clinical Haematology, University Hospital Brest, Brest, France
  3. 3Department of Anatomopathology, University Hospital Brest, Brest, France
  1. Correspondence to Lenaïg Le Clech, lenaig.leclech{at}


Cytomegalovirus (CMV) encephalitis is a rare infection that immunodeficient patients, mainly where HIV-positive, may suffer from. Several cases were described when complications with the treatment with monoclonal antibodies, like rituximab, for malignant lymphomas. We will describe here the case of a patient, who has developed CMV gastritis, then CMV encephalitis after the treatment of a CLL with a chemotherapy and maintenance therapy with rituximab.

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