Anti-S antibodies: an unusual cause of haemolytic disease of the fetus and newborn (HDFN)
- 1Department of Paediatrics, Cavan General Hospital, Cavan, Ireland
- 2Department of Obstetrics & Gynaecology, Cavan General Hospital, Cavan, Ireland
- 3Department of Haematology, Cavan Genaral Hospital, Cavan, Ireland
- Correspondence to Dr Christopher Pitan, docpitan{at}yahoo.co.uk
- Received 13 June 2012
- Revised 28 July 2012
- Accepted 1 August 2012
- Published 3 January 2013
Summary
We report a case of haemolytic disease of the fetus and newborn due to anti-S antibodies. Baby G was born by emergency caesarean section at 35 weeks due to reduced fetal movement. Prior to delivery, antenatal screening revealed the mother's blood group was AB rhesus positive with anti-S antibody titres. The baby was pale but non-hydropic at birth with hepatosplenomegaly. Haemoglobin at birth was 5.23 g/dl and serum bilirubin 138 µmol/l. The baby required phototherapy, γ-globulin infusion and exchange transfusion with post-transfusion complications.








