BMJ Case Reports 2013; doi:10.1136/bcr-2012-006547
  • Unusual presentation of more common disease/injury

Anti-S antibodies: an unusual cause of haemolytic disease of the fetus and newborn (HDFN)

  1. Alan Finan1
  1. 1Department of Paediatrics, Cavan General Hospital, Cavan, Ireland
  2. 2Department of Obstetrics & Gynaecology, Cavan General Hospital, Cavan, Ireland
  3. 3Department of Haematology, Cavan Genaral Hospital, Cavan, Ireland
  1. Correspondence to Dr Christopher Pitan, docpitan{at}
  • Received 13 June 2012
  • Revised 28 July 2012
  • Accepted 1 August 2012
  • Published 3 January 2013


We report a case of haemolytic disease of the fetus and newborn due to anti-S antibodies. Baby G was born by emergency caesarean section at 35 weeks due to reduced fetal movement. Prior to delivery, antenatal screening revealed the mother's blood group was AB rhesus positive with anti-S antibody titres. The baby was pale but non-hydropic at birth with hepatosplenomegaly. Haemoglobin at birth was 5.23 g/dl and serum bilirubin 138 µmol/l. The baby required phototherapy, γ-globulin infusion and exchange transfusion with post-transfusion complications.

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