BMJ Case Reports 2012; doi:10.1136/bcr.12.2011.5369
  • Rare disease

Use of once-weekly statin in combination with ezetimibe in a patient with mitochondrial disease

  1. Jiri Frohlich1
  1. 1Healthy Heart Program Prevention Clinic, Vancouver, Canada
  2. 2Department of Pathology and Laboratory Medicine, St Paul’s Hospital, Vancouver, Canada
  1. Correspondence to Professor Jiri Frohlich, jifr{at}


The authors describe a patient with personal and family history of muscle pains highly suggestive of mitochondrial disease. She presented with familial combined hyperlipidaemia with family history of premature coronary artery disease. After 4-week therapy of 5 mg of rosuvastatin once a week combined with 10 mg of ezetimibe daily, the low-density lipoprotein cholesterol level was markedly decreased from 3.88 to 2.82 mmol/l (27.3% reduction). She has experienced no adverse effects after 6 month treatment. The results suggest that the combination therapy of low-dose once-weekly rosuvastatin and daily ezetimibe could be used as an effective regimen for patients with mitochondrial disease.


  • Competing interests None.

  • Patient consent Obtained.

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