Inam Ulhaq and Adam Abba-Aji have done an excellent case report which it has obvious strengths, it employs the effect of conventional antipsychotic medications (haloperidol )in induction of OCD .Obsessive-compulsive disorder (OCD)-is a neuropsychiatric condition that affects 1-2% of the population and often has an early age at onset of symptoms. OCD has been shown to be familial, and a major gene effect has been reported.( Grados MA, Walkup J, Walford S.) . Obsessive-compulsive symptoms (OCS) are common and clinically significant phenomena in schizophrenia patients and bipolar affective disorders .OCS might modify the expression of psychotic symptoms and bring about complex psychopathological phenomena, psychotic in content and obsessive in form. The relationship between the obsessive compulsive symptoms induced by haloperidol treatment it raise the possibility that it could be related to the effect of the glutamatergic system. Giegling I et al reported that Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol. The brain network which mediates this complex psychopathological effect despite it is rare but it cause clinical significances which stopped only after removing the triggered medications .There is a need for additional research and increased awareness of clinicians for this phenomenon.

Conflict of Interest:

None declared