BMJ Case Reports 2012; doi:10.1136/bcr.02.2012.5815
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Typhlitis: a neutropenic complication

  1. Lokesh Shahani
  1. Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, Illinois, USA
  1. Correspondence to Dr Lokesh Shahani, lokesh83{at}


‘Typhlitis’ describes enterocolitis of the ileocaecal region seen commonly in neutropenic patients. As compared with other malignant conditions, acute myeloid leukaemia (AML) is most often associated with typhlitis.1 The pathogenesis of typhlitis probably involves a combination of factors, including mucosal injury by cytotoxic drugs, profound neutropenia and impaired host defence to invasion by microorganisms.2 The most common chemotherapeutics associated with typhlitis are cytarabine and daunorubicin.1 Peritonitis and perforation are …

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