rss
BMJ Case Reports 2012; doi:10.1136/bcr-2012-010508
  • Neuroimaging

Verification of supraselective drug delivery for retinoblastoma using intra-arterial gadolinium

  1. Ketan R Bulsara5
  1. 1Department of Ophthalmology and Visual Sciences, Yale School of Medicine, New Haven, Connecticut, USA
  2. 2Yale University School of Medicine, New Haven, Connecticut, USA
  3. 3Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA
  4. 4Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut, USA
  5. 5Department of Neurosurgery, Yale University, New Haven, Connecticut, USA
  1. Correspondence to Dr K R Bulsara, Department of Neurosurgery, Yale University, 333 Cedar Street, TMP 4, New Haven, Connecticut 06520, USA; ketan.bulsara{at}yale.edu

Summary

We present a description of retinoblastoma treated with supraselective intra-arterial chemotherapy, demonstrating selective delivery of the infused chemotherapeutic agent into the tumor bed by MRI. A 7-month-old presented with group E (international classification) unilateral retinoblastoma. We treated the patient with several rounds of intra-ophthalmic artery melphalan. Gadolinium was infused along with melphalan to visualize the distribution of this chemotherapeutic drug. Intraoperative MRI was obtained within 15 min after treatment and showed increased enhancement of the tumor and subretinal space. We demonstrate here that supraselective administration of chemotherapy into the ophthalmic artery appears to result in drug delivery to the tumor and subretinal space.

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article