BMJ Case Reports 2012; doi:10.1136/bcr-2012-006803
  • Unexpected outcome (positive or negative) including adverse drug reactions

Reactive amyloidosis complicated by end-stage renal disease 28 years after liquid silicone injection in the buttocks

  1. Alexandre Hertig1,4
  1. 1Department of Urgences Néphrologiques et Transplantation Rénale, APHP, Hôpital Tenon, Paris, France
  2. 2Department of Nuclear Medicine, APHP, Hôpital Tenon, Paris, France
  3. 3Department of Pathology, APHP, Hôpital Tenon, Paris, France
  4. 4Université Pierre et Marie Curie, Paris 6, France
  1. Correspondence to Professor Alexandre Hertig, alexandre.hertig{at}


Silicone ganulomas usually arise from the rupture of silicone implants. Until the 1980s, however, underground care providers used to inject liquid and unapproved silicone directly into human tissues, in the absence of a containing capsule. We report here the case of a man who ultimately developed end-stage renal disease (ESRD) because of a chronic glomerulosclerosis that was attributed to a glomerular AA amyloidosis diagnosed 28 years after a buttock injection of liquid silicone. To our knowledge, this is the first case of a silicone-induced AA amyloidosis irreversibly affecting the kidneys, and leading to ESRD. An interleukin 1 receptor antagonist was started to prevent the extension of amyloidosis, but to no avail as far as the kidneys are concerned. We want to draw the attention of health professionals about the risk of developing AA amyloidosis secondary to a long-lasting inflammation induced by silicone leakage, after a long latency period.

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