BMJ Case Reports 2012; doi:10.1136/bcr-2012-006298
  • Novel treatment (new drug/intervention; established drug/procedure in new situation)

Successful salvage using combined radiation and ABMT for patients with recurrent CNS NGGCT following failed initial transplant

  1. Shawn Malone
  1. Division of Radiation Oncology, The Ottawa Hospital, Ottawa, Canada
  1. Correspondence to Dr Shawn Malone, smalone{at}

Intracranial germ cell tumours (GCTs) are a rare and diverse group of tumours. Histology determines the type of treatment, natural history and prognosis. Germinoma GCTs account for the majority and are very radiosensitive. Conversely, non-germinoma GCTs (NGGCTs) are heterogeneous, relatively radioresistant and have a high risk of relapse despite multimodality therapy. Treatment of recurrence in these patients remains a therapeutic challenge. In this report we review the current literature for treatment of recurrent NGGCTs and present a case of recurrent NGGCT who relapsed despite autologous stem cell transplant (ASCT). The patient was successfully cured using multimodality therapy, consisting of repeat ASCT, intensity modulated radiation therapy and stereotactic radiosurgery.


  • Competing interests None.

  • Patient consent Obtained.

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