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Reminder of important clinical lesson
Clostridium septicum sepsis and its implications
  1. Muhammad Khalid1,
  2. Rajeka Lazarus1,
  3. Ian CJW Bowler1,
  4. Chris Darby2
  1. 1Department of Microbiology and Infectious Diseases, Oxford University Hospital, The John Radcliffe Hospital, Oxford, UK
  2. 2Oxford Transplant Centre, Oxford University Hospital, Churchill Hospital, Oxford UK
  1. Correspondence to Dr Rajeka Lazarus, dr_osama_khalid{at}hotmail.com, Muhammad.khalid{at}orh.nhs.uk

Summary

An elderly gentleman, who had 12 years earlier been successfully treated for colon cancer, presented with fever, rigours, right upper quadrant abdominal pain and tenderness. A CT of the abdomen revealed a colonic mass distal to the hepatic flexure with multiple gas locules and a walled off perforation. He underwent a right hemicolectomy. Histology confirmed multifocal colonic adenocarcinoma. His admission blood cultures grew Clostridium septicum. A week postoperatively he developed intermittent fevers and abdominal pain. Repeat CT revealed an abdominal collection adjacent to the new anastomosis, but more importantly, a sharply shouldered aneurysmal dilation of the infra-renal abdominal aorta. These findings prompted immediate surgical drainage of the collection, repair of the anastomostic leak, resection of the infected aortic aneurysm and replacement with a tube graft. This case highlights the clinical significance of C septicum bacteraemia: its association with occult colonic malignancy and with mycotic aneurysm formation. Clostridia isolated from blood cultures should not be dismissed as contaminants but fully identified to ensure appropriate patient management.

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