BMJ Case Reports 2012; doi:10.1136/bcr-03-2012-6012
  • Reminder of important clinical lesson

Bee-sting, a non-resolving wound and a progressive mass over the right eye preceding the ultimate diagnosis of frontal bone Ewing's sarcoma

  1. Swaroop Revannasiddaiah
  1. Department of Radiation Therapy and oncology, Regional Cancer Centre, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India
  1. Correspondence to Dr Swaroop Revannasiddaiah, swarooptheone{at}

A healthy young lady suffered a bee-sting over her right eyelid which was followed by pain, redness and swelling at, above and beyond the right eyelid. Although the initial swelling subsided, the patient noticed a small ‘lump’, superior to the eyelid which persisted after the rest of the swelling disappeared. This lump subsequently progressed over a span of 3 months and then caused ulceration of the overlying skin. Further testing revealed the lump to be an Ewing's sarcoma arising from the frontal bone. The patient was treated with standard chemotherapy (16 cycles of vincristine, doxorubicin, cyclophosphamide alternating with cycles of ifosfamide and etoposide) and radiotherapy and has remained disease-free 18-months after completion of treatment. This report reminds the reader about a not-so-uncommon mode of presentation of malignancies, that is, they being discovered after attention drawn by a rather common injury or trauma.


  • Competing interests None.

  • Patient consent Obtained.

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