rss
BMJ Case Reports 2012; doi:10.1136/bcr-03-2012-5973
  • Findings that shed new light on the possible pathogenesis of a disease or an adverse effect

A rare but severe pulmonary side effect of cetuximab in two patients

  1. Huldrych F Günthard1
  1. 1Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, University of Zurich, Zurich, Switzerland
  2. 2Department of Radiology, University Hospital Zurich, Zurich, Switzerland
  3. 3Division of Radiation Oncology, University Hospital Zurich, Zurich, Switzerland
  4. 4Department of Clinical Pharmacology and Toxicology, University Hospital Zurich, Zurich, Switzerland
  1. Correspondence to Dr Yvonne Achermann, yvonne.achermann{at}gmail.com

Cetuximab is a monoclonal antibody that treats malignant disease by inhibiting epidermal growth factor receptor. Many common adverse events have been reported and include skin rashes, infusion reactions, gastrointestinal complaints and headache. Up to now, cetuximab-associated pulmonary toxicity has been rarely reported in the literature. The present report describes two cases with probable interstitial pneumonitis 5–6 weeks after commencing treatment with chemotherapy combined with cetuximab. One patient recovered and the second patient died due to gastrointestinal bleeding 3 weeks after an initial response to steroids.

Footnotes

  • Competing interests None.

  • Patient consent Obtained.

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article