BMJ Case Reports 2011; doi:10.1136/bcr.12.2010.3579
  • Findings that shed new light on the possible pathogenesis of a disease or an adverse effect

NMDA receptor encephalitis – expanding the clinical spectrum

  1. Husam Ali2
  1. 1Neurology Department, Sunderland royal hospital, Sunderland, Tyne and Wear, UK
  2. 2Neurology Department, RVI, Newcastle upon Tyne, UK
  1. Correspondence to Dr Uma Nath, uma.nath{at}


A young woman presented with memory problems of subacute onset. Imaging was normal. She was admitted with severe complex partial status epilepticus requiring intensive care support and ventilation. Fits proved difficult to control requiring high dose anticonvulsants. She developed a profound amnesic syndrome. A clinical diagnosis of autoimmune encephalitis was considered and she was treated with intravenous steroids with an excellent cognitive outcome. She continues to have occasional seizures.


  • Competing interests None.

  • Patient consent Obtained.

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