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BMJ Case Reports 2011; doi:10.1136/bcr.06.2011.4369
  • Rare disease

Vanishing bile duct syndrome in a HIV patient on HAART therapy

  1. Michael Virata3
  1. 1Department of Internal Medicine, Hospital of Saint Raphael, New Haven, Connecticut, United States
  2. 2Department of Pathology, Hospital of Saint Raphael, New Haven, Connecticut, United States
  3. 3Department of Infectious Disease, Hospital of Saint Raphael, New Haven, Connecticut, United States
  1. Correspondence to Dr Jerome Gnanaraj, jgnanaraj{at}srhs.org

Summary

Vanishing bile duct syndrome refers to a group of disorders characterised by progressive destruction of the intrahepatic bile ducts resulting in cholestasis. It is a final common pathway for many disorders. The diagnoses is mainly made by histological findings. To consider a diagnosis there should be loss of interlobular bile ducts in more than fifty per cent of small portal tracts provided that the specimen contains at least 10 portal tracts. Here the authors present a case of vanishing bile duct syndrome which developed after initiation of highly active antiretroviral treatment therapy.

Footnotes

  • Competing interests None.

  • Patient consent Obtained.

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