BMJ Case Reports 2011; doi:10.1136/bcr.06.2011.4330
  • Unusual association of diseases/symptoms

An unusual case of DRESS syndrome due to leflunomide

  1. Sudhir Kumar Verma1
  1. 1Department of Internal medicine, CSM Medical University, Lucknow, Uttar Pradesh, India
  2. 2Department of Pulmonary medicine, CSM Medical University, Lucknow, Uttar Pradesh, India
  1. Correspondence to Professor Arvind Kumar Vaish, vaish12{at}


The DRESS (drug rash, eosinophilia and systemic symptoms) syndrome, is a type of drug hypersensitivity syndrome, is a severe idiosyncratic reaction to several drugs, mainly antiepileptics and antibiotics, which can occasionally produce acute hepatic failure. In this article, the authors report a case of DRESS syndrome with severe exfoliative dermatitis with acute hepatitis associated with intake of leflunomide. Rapid diagnosis with withdrawal of offending agent is crucial for survival of these cases.


  • Competing interests None.

  • Patient consent Obtained.

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