BMJ Case Reports 2011; doi:10.1136/bcr.05.2011.4287
  • Novel treatment (new drug/intervention; established drug/procedure in new situation)

Hepatitis B virus related membranous glomerulonephritis and proteinuria treated with lamivudine and tenofovir

  1. Stephen Holt3
  1. 1Department of Nephrology and Transplantation, Guy and St Thomas Hospitals, NHS Foundation Trust, London, UK
  2. 2Sussex Kidney Unit, Brighton and Sussex University Hospitals NHS Trust, Brighton, East Sussex, UK
  3. 3Monash University, Clayton, Victoria, Australia
  1. Correspondence to Dr Partha Das, parthadas{at}


Membranous glomerulonephritis is the most common histological renal lesion associated with hepatitis B virus (HBV) infection. The authors describe here a case of a patient presenting with the nephrotic syndrome and HBV infection but without progressive liver disease. The use of lamivudine and tenofovir resulted in arrest of proteinuria and stabilisation of renal function.


  • Competing interests None.

  • Patient consent Obtained.

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