BMJ Case Reports 2011; doi:10.1136/bcr.04.2011.4163
  • Unusual association of diseases/symptoms

Paraneoplastic hyperthyroidism

  1. Christoph Schmid1
  1. 1Endocrinology Department, University Hospital Zurich, Zurich, Switzerland
  2. 2Oncology Department, University Hospital Zurich, Zurich, Switzerland
  1. Correspondence to Dr Sibylle Kohler, sibskohler{at}


The authors describe a 31-year-old male with a metastatic germ cell tumour and massively elevated human chorionic gonadotrophin (HCG) levels who presented with hyperthyroidism. As HCG is structurally closely related to thyroid stimulating hormone (TSH), it can activate the TSH receptor; grossly elevated levels may result in hyperthyroidism. After initiation of chemotherapy, HCG levels decreased and hyperthyroidism resolved.


  • Competing interests None.

  • Patient consent Obtained.

Register for free content

The full text of all Editor's Choice articles and summaries of every article are free without registration

The full text of Images in ... articles are free to registered users

Only fellows can access the full text of case reports (apart from Editor's Choice) - become a fellow today, or encourage your institution to, so that together we can grow and develop this resource

Don't forget to sign up for content alerts so you keep up to date with all the case reports as they are published, and let us know what you think by commenting on the Editor's blog

Navigate This Article