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Unexpected outcome (positive or negative) including adverse drug reactions
Lamotrigine-induced toxic epidermal necrolysis in a young epileptic

Summary

A 20-year-old young female presented with extensive skin rashes with bullae and extensive epidermal necrolysis about 20 days after the addition of lamotrigine (LTG) to her anticonvulsant medication. The patient was managed by stopping LTG and supportive treatment. The seizures were controlled with increase in the doses of carbamazepine. The report emphasises exercising of caution once LTG is added to a regimen containing valproic acid.

https://doi.org/10.1136/bcr.04.2011.4149

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