Neurocysticercosis case with tuberculoma-like epithelioid granuloma strongly suspected by serology and confirmed by mitochondrial DNA
- Takuya Maeda1,2,
- Akira Ito3,
- Yasuhito Sako3,
- Hiroshi Yamasaki3,
- Naoki Oyaizu4,
- Takashi Odawara2,
- Aikichi Iwamoto2,
- Takeshi Fujii2
- 1Division of Infectious Diseases and Pulmonary Medicine, Department on Internal Medicine 2, National Defense Medical College, Tokorozawa, Saitama, Japan
- 2Department of Infectious Diseases and Applied Immunology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan
- 3Department of Parasitology, Asahikawa Medical University, Asahikawa, Hokkaido, Japan
- 4Department of Laboratory Medicine, The Institute of Medical Science, The University of Tokyo, Minato-ku, Tokyo, Japan
- Correspondence to Takuya Maeda,
An Indian woman with multiple and nodular cerebral lesions presenting epithelioid granulomas was diagnosed as suspected malignant tumours and the biopsy was carried at local hospital in Japan. The specimen was pathologically diagnosed as tuberculoma. However, due to her nationality, the authors suspected it to be neurocysticercosis (NCC) and carried out serology and applied mitochondrial DNA analysis of Taenia solium. These diagnostic tools revealed it as NCC radiologically and pathologically mimicking central nervous tuberculomas. Molecular confirmation of NCC cases is strongly recommended when we can get the biopsy specimens.
Competing interests None.
Patient consent Not obtained.