BMJ Case Reports 2011; doi:10.1136/bcr.03.2011.4007
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Ten-year follow-up after autologous stem cell transplantation of a patient with immunoglobulin light-chain (AL) amyloidosis with deposits in the heart, liver and gastrointestinal tract

  1. Izabella Janczewska3
  1. 1Department of Clinical Sciences, Ersta Hospital and Karolinska Institutet, Danderyd Hospital,Stockholm, Sweden
  2. 2Karolinska Institutet, Hematology Center, Karolinska University Hospital, Stockholm, Sweden
  3. 3Department of Clinical Sciences, Division of Internal Medicine, Karolinska Institutet, Stockholm, Sweden
  1. Correspondence to Dr Izabella Janczewska, izabella.janczewska{at}


The prognosis in amyloid light chain (AL)-amyloidosis and multiorgan involvement is poor, with a high-treatment-related mortality after high-dose melphalan and autologous stem cell transplantation (HDM/SCT). Some patients, however, might benefit from the therapy. We report a case of cardiac AL-amyloidosis with multiorgan involvement where the progressive cardiomyopathy was halted after successful treatment with HDM/SCT in 2001. The patient is in an excellent cardiac condition with a good quality of life, receiving treatment with angiotensinogen receptor blockers and a flexible diuretics regimen at follow-up after 10 years.


  • Competing interests None.

  • Patient consent Not obtained.

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