Chemotherapy improves thymoma-associated graft-versus-host-disease-like erythroderma
- Tatsuya Nagano1,
- Yoshikazu Kotani1,
- Kazuyuki Kobayashi1,
- Nanako Tomita1,
- Kyosuke Nakata1,
- Akihiro Sakashita1,
- Yasuhiro Funada1,
- Hiroshi Nagai2,
- Tomoo Itoh3,
- Yoshihiro Nishimura1
- 1Division of Respiratory Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
- 2Division of Dermatology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
- 3Department of Diagnostic Pathology, Kobe University Graduate School of Medicine, Kobe, Japan
- Correspondence to Dr Kazuyuki Kobayashi,
Graft-versus-host-disease (GVHD) with erythroderma can rarely occur in the context of thymoma and is associated with a poor prognosis due to an increased risk of infection-related death. The present study describes a case of a 50-year-old man with malignant thymoma who developed sepsis in addition to skin manifestations similar to that seen in GVHD. This patient experienced marked improvement in skin lesions in response to steroids and combination chemotherapy with carboplatin and paclitaxel, with subsequent resolution of infection. The present study describes the clinical course of this patient, followed by a review of pertinent reports of thymoma associated with GVHD with particular focus on the efficacy of treatment strategies.
Competing interests None.
Patient consent Obtained.