BMJ Case Reports 2011; doi:10.1136/bcr.02.2011.3850
  • Unusual association of diseases/symptoms

Pituitary involvement in Wegener’s granulomatosis: unusual biochemical findings and severe malnutrition

  1. Barbara Mcgowan4
  1. 1Diabetes and Endocrinology Department, Guy and St Thomas Hospital, London, UK
  2. 2Neurology Department, Ciudad Real Hospital, Ciudad Real, Spain
  3. 3Endocrinology Department, Ciudad Real Hospital, Ciudad Real, Spain
  4. 4Department of Endocrinology, Guy and St Thomas NHS Trust, London, UK
  1. Correspondence to Dr Carmen Tenorio Jimenez, carmen.tenorio{at}


Wegener’s granulomatosis (WG) is a systemic disease with a complex genetic background. It is characterised by inflammation of the small blood vessels leading to damage in any number of organs. The common features include granulomatous inflammation of the respiratory tract and kidneys. Most patients have measurable autoantibodies against neutrophil proteinase-3 (Antineutrophil Cytoplasmic Antibody, ANCA). Pituitary involvement is a rare complication of this disease and, when it occurs, diabetes insipidus is the most common manifestation. We describe a 38-year-old female with known long-term WG who presented with partial hypopituitarism, severe malnutrition and ANCA negative status, with a favourable response to steroid pulse therapy.


  • Competing interests None.

  • Patient consent Obtained.

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