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Learning from errors
Recurrent mycobacterial infections in a patient with IL-12 deficiency
  1. Matthew Buckland1,
  2. Roshanara Ali1,
  3. Graham Bothamley2,
  4. David Lammas3,
  5. Rainer Doffinger4,
  6. Hilary Longhurst5
  1. 1
    Barts and the London NHS Trust, Immunology, 214, 80 Newark St, London E1 2ES, UK
  2. 2
    Homerton Hospital, Homerton University Hospital NHS Foundation Trust, London E9 6SR, UK
  3. 3
    Birmingham University, Clinical Immunology, Edgbaston, Birmingham B15 2TT, UK
  4. 4
    Addenbrooke’s Hospital, Clinical Immunology, Hills Road, Cambridge CB2 2QQ, UK
  5. 5
    Barts and the London NHS Trust, Clinical Immunology, 80 Newark St, London E1 2ES, UK
  1. Matthew Buckland, msbuckland{at}gmail.com

Summary

This case of a middle aged woman with IL-12p40 deficiency and recurrent Mycobacterium kansasii infection demonstrates that in vitro sensitivities do not reliably predict the clinical response of non-tuberculous mycobacteria (NTMB), and emphasises the need to exercise caution when reducing treatment intensity in patients with type 1 cytokine defects on the basis of in vitro minimum inhibitory concentration (MIC) data alone.

https://doi.org/10.1136/bcr.11.2008.1278

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    Footnotes

    • Competing interests: None.