Article Text
Summary
Abscess formation following immunisation is a previously reported complication, generally associated with microbial contamination of the vaccine. Less commonly, such abscesses have been sterile. Here we describe two children evaluated in the Center for Disease Control and Prevention (CDC)-funded Clinical Immunization Safety Assessment (CISA) network who developed recurrent sterile abscesses after administration of vaccines containing aluminium adjuvant, either individually or in combination. Although the abscesses healed without sequelae, these occurrences support an association between receipt of aluminium adjuvant and sterile abscesses in susceptible patients. For patients with similar symptoms, clinicians may wish to choose a vaccine formulation containing the least amount of aluminium adjuvant.
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Footnotes
Competing interests: NP Klein reports receiving research support from CDC, GlaxoSmithKline, Sanofi Pasteur, Novartis, Merck & Co and MedImmune. KM Edwards reports receiving research support from NIH, CDC, Wyeth, Sanofi Pasteur and Novartis. CL Dekker receives research support from NIH and CDC.
Patient consent: Patient/guardian consent was obtained for publication