BMJ Case Reports 2009; doi:10.1136/bcr.08.2008.0824
  • Novel treatment (new drug/intervention; established drug/procedure in new situation)

Delayed therapeutic hypothermia following cardiac arrest secondary to chloroquine toxicity

  1. George Mark Haslam,
  2. Matt C Thomas,
  3. Stephen R Laver
  1. Royal United Hospital, Anaesthesia, Royal United Hospital, Combe Park, Bath BA1 3NG, UK
  1. George Mark Haslam, gmarkhaslam{at}
  • Published 6 March 2009


We describe a case of severe chloroquine intoxication resulting in a cardiac arrest requiring prolonged cardiopulmonary resuscitation. An excellent neurological outcome was achieved because the cardiac arrest occurred in a young patient lacking comorbidities in an environment where advanced life support was provided rapidly and effectively. Therapeutic hypothermia was instigated once profound shock and arrhythmias had resolved, and this may have contributed to her recovery. If a patient’s immediate clinical condition post-cardiac arrest precludes therapeutic hypothermia, the use of this therapy should be reconsidered as their condition changes.


  • Competing interests: none.

  • Patient consent: Patient/guardian consent was obtained for publication.

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