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BMJ Case Reports 2009; doi:10.1136/bcr.08.2008.0709
  • Findings that shed new light on the possible pathogenesis of a disease or an adverse effect

Hypocretinergic dysfunction in neuromyelitis optica with coma-like episodes

  1. B Carlander1,
  2. T Vincent2,
  3. A Le Floch1,
  4. N Pageot1,
  5. W Camu1,
  6. Y Dauvilliers1,3
  1. 1
    Department of Neurology, Hôpital Gui-de-Chauliac, Montpellier, France
  2. 2
    Immunology Laboratory, Hôpital Saint-Eloi, Montpellier, France
  3. 3
    INSERM U888, Hôpital de la Colombière, Montpellier, France
  1. b-carlander{at}chu-montpellier.fr
  • Published 2 February 2009

Summary

Devic’s neuromyelitis optica (NMO) is a severe demyelinating disease of the central nervous system, often misdiagnosed as multiple sclerosis, and involving mainly optic nerves and the spinal cord. We report on a peculiar case of relapsing NMO with severe recurrent dysautonomia and hypersomnia, in which we had the opportunity to observe a dramatic decrease in hypocretin/orexin cerebrospinal fluid level.

Footnotes

  • Competing interests: None.

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