BMJ Case Reports 2009; doi:10.1136/bcr.08.2008.0643
  • Rare disease

Dramatic response to levetiracetam in post-ischaemic Holmes’ tremor

  1. P Striano1,2,
  2. Andrea Elefante1,
  3. Antonietta Coppola1,
  4. Fabio Tortora1,
  5. Federico Zara2,
  6. Carlo Minetti2
  1. 1
    Federico II University, Via Pansini 5, Naples, 80131, Italy
  2. 2
    G. Gaslini Insit, Largo Gaslini 5, Genova, 16124, Italy
  1. sstriano{at}
  • Published 23 January 2009


Holmes’ tremor refers to an unusual combination of rest, postural and kinetic tremor of extremities. Common causes of Holmes’ tremor include stroke, trauma, vascular malformations and multiple sclerosis, with lesions involving the thalamus, brain stem or cerebellum. Although some drugs (eg, levodopa and dopaminergic drugs, clonazepam and propranolol) have been occasionally reported to give some benefit, medical treatment of Holmes’ tremor is unsatisfactory, and many patients require thalamic surgery to achieve satisfactory control. We report a patient in whom post-ischaemic Holmes’ tremor dramatically responded to levetiracetam treatment.


  • Competing interests: None.

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